Throughout our series of informative blogs, we have focused on a variety of diseases and conditions which have been effectively managed utilizing SVF (Stromal Vascular Fraction) derived from the patient’s own adipose tissue. This multipotent “cellular soup” has been used for almost 50 years throughout the world, initially in research studies but over the past 20 years in therapeutics; and the evidence is perceived to be overwhelmingly positive. These cellular therapy tools hold great promise in the management of various diseases as well as assisting in repairing damage such as large-scale skin damage from burns, post-cancer irradiation injury, and trauma. For more information on how these multipotent regenerative agents of change impact the health outcomes of patients with osteoarthritis, erectile dysfunction, cardiac conditions, or critical limb ischemia please visit our website and read our backlog of blogs.

Recap – Stromal Vascular Fraction(SVF) Stem Cell Therapy

To recap and to provide context, Stromal Vascular Fraction (SVF) represents a prolific source of adult stem cells and other regenerative cellular agents to aid the body in healing and repairing damage. This “multipotency” comes from the innate ability of the regenerative stem cells to differentiate into whatever the body requires.  SVF/ADSC’s (Adipose-Derived Stem Cells) injected into a failing heart repairs and replaces damaged cardiac muscle, blood vessels, and connective tissue. The same is true for an arthritic knee, as ADSCs repair the cartilage and strengthen the joint tissues themselves while increasing blood flow and mobility. Autologous (originating within the patient’s own body as opposed to engineered or from a donor) fat deposits which exist naturally in every human body are a rich source of these cells. In fact, this “gumbo” of beneficial cellular material naturally contains not only adult mesenchymal stem cells, but also growth factors, other endothelial progenitor cells, T-cells, and macrophages. What science didn’t know until fairly recently, however, is that adipose tissue also contains hematopoietic stem cells (HSPCs) or Bone Marrow Stem Cells (BMSCs), which are the progenitor cells designated C34 that had been previously thought to exist only in bone marrow.

GCSC Adipose Tissue As A Potential Source Of HSPCs

Hematopoietic Stem Cells

Hematopoietic Stem and Progenitor Cells (HSPCs/ BMSCs) are juvenile cells which can potentially differentiate into every type of blood cell, including white blood cells, red blood cells, and platelets. Found in the peripheral blood and the bone marrow, HSPCs meet the body’s need to produce around 500 billion new blood cells (20 grams of hemoglobin) per day and the precise regulation of the number and ratio of each type in circulation. The vast majority of hematopoiesis (the process of creating new blood cells) occurs in the bone marrow and is accomplished by a limited number of HSPCs which are multipotent and capable of nearly-endless self-renewal. Despite their immense and vital importance, only one in 20 thousand marrow cells are BMSCs. So far, these stem cells sound very similar in presentation and behavior to the adipose stem cells, which are the subject of the majority of our blogs.

It is widely known in the medical community that, while the process to harvest and apply ADSC’s is quick, painless, and cost-effective, the procedure required to utilize bone marrow-derived stem cells is anything but. However, new research has shown the presence of substantial numbers of HSPCs within adipose tissue, and vice versa. In fact, the biochemical and molecular composition of peripheral adipose tissue and bone marrow share a lot of similarities. Both environments are composed of stromal cells and a rich extracellular matrix, both possess low tissue oxygenation and express a wide variety of homing factors that may facilitate the trafficking of bone marrow stromal cells between environments. The presence of stromal cells, as well as the extracellular matrix, not only provide a level of structural support but also strongly influence several important immune-related processes.

Due to the fact that the molecular composition of adipose tissue seems to share significant similarities with bone marrow, and their resulting stem cell populations, it is believable that an adipose tissue environment may offer suitable conditions for freely-circulating HSPCs to settle down. While it has been almost 50 years since adipose tissue has been identified as a key component in immunometabolism, through continued and varied research efforts we are still finding new and innovative ways to utilize it. Despite its well-known involvement in the regulation of immune and endocrine homeostasis, research has proven that adipose tissue also contains a considerable number of HSPCs which have migrated and “settled down” throughout the lifespan of the patient. This process begins in the first decade of life, with adipose tissue appearing in bone marrow cavities beginning in the distal limb bones. The process progresses proximally with age, with a particular increase during puberty, but extends throughout the human lifespan. This means that valuable adipose tissue is readily available when age-related degeneration begins to show, and regenerative medicine is ready with therapeutic solutions for many of our life’s medical and physical woes.

Contact Gulf Coast Stem Cell

At Gulf Coast Stem Cell Regenerative Center, we conduct patient-funded research with the intention of helping our patients manage advanced medical conditions with their own autologous stem cells. We aid in the management of autoimmune, degenerative, inflammatory, and ischemic conditions, and our highly skilled team of providers is committed to the goal of alleviating symptoms, enhancing functionality, and improving overall quality-of-life for our patients. Contact Gulf Coast Stem Cell and Regenerative Medicine Center and let us show you what “Excellence with a Human Touch” means. For more information on the full list of diseases and disorders that we currently address, please call (866) 885-4823 or contact us via our website today!

Download: GCSC June 2018 Adipose Tissue As A Potential Source Of HSPCs

Original Research Article Information