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Rheumatoid Arthritis Library

Fat-Derived Stem Cells bring Regeneration to Degenerative Joint Disease Sufferers

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Degenerative Joint Disease Commonly called “degenerative joint disease,” (DJD), osteoarthrosis or osteoarthritis (OA) is the commonest form of arthritis. It is ubiquitous and causes the afflicted joints to deteriorate or “degenerate” progressively, losing articular cartilage, eroding into bone, often accompanied by ligament laxity. The disease affects approximately 27 million Americans…

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Stem Cells in Orthopedic Research

By | Knee Surgery Library, Rheumatoid Arthritis Library, Stem Cell Research Studies, Uncategorized | No Comments

For many of the millions of arthritis sufferers, stem cell research seems like an exciting prospect in a dystopian healthcare system advocating debilitating surgeries and progressively higher doses of steroids.  Luckily, stem cell therapy is becoming an increasingly popular alternative treatment for a variety of conditions, including degenerative joint disease…

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Regulation of TNFalpha and IL1beta in rheumatoid arthritis synovial fibroblasts by leukotriene B4.

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Rheumatol Int. 2010 Jul;30(9):1183-9 Authors: Xu S, Lu H, Lin J, Chen Z, Jiang D Arachidonic acid metabolites, such as leukotriene B4 (LTB4), are known to play an important role in pathogenesis of rheumatoid arthritis (RA). Apart from leukocytes, RA synovial fibroblasts (RASF) produce a broad array of inflammatory mediators…

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Monoclonal antibodies: new therapeutic agents for autoimmune hemolytic anemia?

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Endocr Metab Immune Disord Drug Targets. 2008 Mar;8(1):62-8 Authors: D’Arena G, Taylor RP, Cascavilla N, Lindorfer MA Conventional treatment of autoimmune hemolytic anemia (AIHA) comprises corticosteroids and splenectomy and/or other immunosuppressive drugs for refractory/relapsed patients. Monoclonal antibodies (MoAbs) rituximab and alemtuzumab have gained widespread acceptance in the management of B-cell…

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Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts.

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Biochem Biophys Res Commun. 2008 Jun 13;370(4):599-602 Authors: Palmer CD, Mutch BE, Page TH, Horwood NJ, Foxwell BM Discordant cytokine production is characteristic of chronic inflammatory conditions like rheumatoid arthritis (RA), and anti-cytokine therapeutics are becoming routinely used to treat RA in the clinic. Fibroblasts from rheumatoid synovium have been…

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Tumor necrosis factor-alpha inhibits chondrogenic differentiation of synovial fibroblasts through p38 mitogen activating protein kinase pathways.

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Mod Rheumatol. 2008;18(4):366-78 Authors: Okuma-Yoshioka C, Seto H, Kadono Y, Hikita A, Oshima Y, Kurosawa H, Nakamura K, Tanaka S We previously reported that synovial fibroblast-like cells (SFs) can be differentiated into chondrocytes through activin receptor-like kinase (ALK) 3 activation. The aim of this study was to clarify the effect…

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Multipotent mesenchymal stromal cells in articular diseases.

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Best Pract Res Clin Rheumatol. 2008 Apr;22(2):269-84 Authors: Jorgensen C, Djouad F, Bouffi C, Mrugala D, Noël D Although cartilage defects are common features of osteoarthritis and rheumatoid arthritis, current treatments can rarely restore the full function of native cartilage. Recent studies have provided new perspectives for cartilage engineering using…

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Evaluation of COX-1/COX-2 selectivity and potency of a new class of COX-2 inhibitors.

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Eur J Pharmacol. 2008 Jun 24;588(1):93-8 Authors: Gierse J, Nickols M, Leahy K, Warner J, Zhang Y, Cortes-Burgos L, Carter J, Seibert K, Masferrer J A new class of selective cyclooxygenase-2 (COX-2) inhibitors has been identified by high throughput screening. Structurally distinct from previously described selective COX-2 inhibitors, these benzopyrans…

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Effects of a tetramethoxyhydroxyflavone p7f on the expression of inflammatory mediators in LPS-treated human synovial fibroblast and macrophage cells.

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J Microbiol Biotechnol. 2008 Apr;18(4):686-94 Authors: Yoon DY, Cho MC, Kim JH, Kim EJ, Kang JW, Seo EH, Shim JH, Kim SH, Lee HG, Oh GT, Hong JT, Park JW, Kim JW The inhibitory effects of 5,6,3′,5′-tetramethoxy 7,4′-hydroxyflavone (labeled as p7F) were elucidated on the productions of proinflammatory cytokines as…

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