MSC response to pH levels found in degenerating intervertebral discs.

Biochem Biophys Res Commun. 2009 Feb 20;379(4):824-9
Authors: Wuertz K, Godburn K, Iatridis JC

Painful degenerative disc disease is a major health problem and for successful tissue regeneration, MSCs must endure and thrive in a harsh disc microenvironment that includes matrix acidity as a critical factor. MSCs were isolated from bone marrow of Sprague-Dawley rats from two different age groups (

PMID: 19133233 [PubMed – indexed for MEDLINE]