Clin Sports Med. 2001 Apr; 20(2) : 403-16, viii.
Treatment of osteochondral injuries. Genetic engineering.
Articular cartilage injuries are commonly encountered problems in sports medicine and orthopaedics. The treatment of chondral and osteochondral lesions, which possess only a very limited potential for healing, still represents a great challenge to clinicians and to scientists. Experimental investigations reported over the last 20 years have shown that a variety of methods, including implantation of periosteum, perichondrium, artificial matrices, growth factors, and transplanted cells, can stimulate formation of new cartilage. Genetic engineering–a combination of gene transfer techniques and tissue engineering will facilitate new approaches to the treatment of articular cartilage injuries.
PMID: 11398365 [PubMed – indexed for MEDLINE]