Cell Transplant. 2010 Sep 30.
The treatment of neurodegenerative disorders using umbilical cord blood and menstrual blood derived stem cells.
Sanberg PR, Eve DJ, Willing AE, Garbuzova-Davis S, Tan J, Sanberg CD, Allickson JG, Cruz LE, Borlongan CV.
Center Of Excellence for Aging and Brain Repair, Dept. Neurosurgery and Brain Reapir, University of South Florida, Tampa FL, firstname.lastname@example.org.
Stem Cell transplantation is a potentially important means of treatment for a number of disorders. Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual blood-derived stem cells. These cells are relatively easy to obtain, appear to be pluripotent and are immunologically immature. These cells, particularly umbilical cord blood cells, have been studied as either single or multiple injections in a number of animal models of neurodegenerative disorders with some degree of success, including stroke, Alzheimer’s disease, amyotrophic lateral sclerosis, and Sanfilippo syndrome type B. Evidence of anti-inflammatory effects and secretion of specific cytokines and growth factors that promote cell survival, rather than cell replacement have been detected in both transplanted cells.
PMID: 20887684 [PubMed – as supplied by publisher]