Asthma is a common chronic inflammatory disease of the airways characterized by symptoms including wheezing, coughing, chest tightness, and shortness of breath, reversible airflow obstruction, and bronchospasm. Asthma is clinically classified according to the frequency of symptoms, forced expiratory volume in 1 second (FEV1), and peak expiratory flow rate. Asthma may also be classified as atopic (extrinsic) or non-atopic (intrinsic). It can be exercised induced or occupational. Asthma affects an estimated 300 million people worldwide and caused 250,000 deaths in 2009. Traditional management usually focuses on reduction to allergen exposure and medical therapy that consists of beta-2-agonists, anti-cholinergics, or inhaled corticosteroids.
Lung injuries are leading causes of morbidity and mortality worldwide. Pulmonary diseases such as asthma or chronic obstructive pulmonary disease characterized by loss of lung elasticity, small airway tethers, and luminal obstruction with inflammatory mucoid secretions, or idiopathic pulmonary fibrosis characterized by excessive matrix deposition and destruction of the normal lung architecture, have essentially symptomatic therapies and their management is costly to the health care system. Regeneration of tissue by stem cells from endogenous, exogenous, and even genetically modified cells is a promising novel therapy. The use of adult stem cells to help with lung regeneration and repair could be a newer technology in clinical and regenerative medicine. In fact, different studies have shown that bone marrow progenitor cells contribute to repair and remodeling of lung in animal models of progressive pulmonary hypertension. Therefore, lung stem cell biology may provide novel approaches to therapy and could represent a great promise for the future of molecular medicine. In fact, several diseases can be slowed or even blocked by stem cell transplantation.
Asthma – Gulf Coast Stem Cell & Regenerative Medicine Center
Research has been ongoing around the world that exploits the anti-inflammatory and immuno-modulatory properties of adult stem cells to control the reactive airways associated with asthma. Gulf Coast Stem Cell & Regenerative Medicine Center(GCSC&RMC) is investigating the effects of SVF (rich in mesenchymal stem cells and growth factors) on chronic asthma. Our Cell Surgical Network(CSN) has developed a protocol that includes a combination of intravenous and nebulized SVF delivery. The deployment protocol is performed under local anesthesia is all done as an outpatient at the time of SVF harvesting and procurement. The entire cellular surgical procedure takes approximately 3 hours.
We at Gulf Coast Stem Cell & Regenerative Medicine Center(GCSC&RMC) care about our Asthma patients and understand their difficulties. We take pride in the time we spend caring for them and deploying, we believe, the best protocol to help them achieve their goals.